How to come in Luberon ? Find a way from UK or the rest of the world, by train TGV Avignon, Aix en Provence, by plane in Marseille, Avignon or by bus.
Highway A7 to Avignon: take exit 26 - Senas. Take direction Mallemort, Cadenet, D973 until Pertuis and take direction La Tour d'Aigues.
Highway La Provençale A8 from Nice: take direction Aix, then take the A51 direction Gap. Take the exit N°15: Pertuis. Cross Pertuis direction D956, La Tour d'Aigues.
Highway A51 from Gap, take direction Aix - Marseille. Take the exit N°15: Pertuis. Cross Pertuis direction D956, La Tour d'Aigues.
The closest airports to the Luberon are Marseille (1 hour), Nimes (1hr 15), and Montpellier (1hr 40). These airports have direct flights from the UK and Europe, but not transatlantic. Avignon airport is even closer, 40 minutes, but only has internal flights and the odd one from the UK. The busiest airport in Provence is Nice, which does have non-stops from New York and Montreal, and Nice is 2.5 hours drive from the Luberon.
From North America, you will typically arrive in France at Paris CDG airport. From here or Paris itself you can catch the
TGV fast train down to Avignon or Aix, or an onward flight to Marseille. The train takes 2 hours 40 minutes and the flight is 1 hour.
From the UK
There are many low-cost flights from various UK airports to Marseille, Avignon, Nimes or Montpellier. On arrival you would rent a car to get around. British Airways also has flights from London Gatwick to Marseille, and if you book far ahead this would not necessarily cost more than a budget airline.
You also have the option of taking a Eurostar train to Lille and then TGV train down to Avignon or Aix. (You can also Eurostar to Paris but then you have to change station rather than platform as at Lille). On Saturdays there is a direct Eurostar train from London to Avignon that takes about 6 hours.
If you drive down from the UK you can take a ferry across the channel. It will take about 10 hours from Calais to the Luberon, given clear traffic conditions.
From the rest of the world
You will most likely fly into Paris CDG airport. From here you can connect to an Air France flight down to Marseille (1 hour), then rent a car to the Luberon (1 hour).
Perhaps the better option from Paris CDG is to take the train. The TGV (fast train) takes 2 hours and 40 minutes to Avignon TGV station. There you can rent a car from all the major companies, and be in the Luberon in 45 minutes.